So, called by Google search, the best example of MathJax web page:

https://sitebuilder.princeton.edu/module/mathjax

1. enabling Chrome "Menu/Settings/MoreTools/Reading Mode", trows user to different page
   MathJax script is shown instead of expression, so page is corrupt.
   User have to do a guess work, click on "tools" icon and enable side view.
   
3. MathJax expression is read literally as a script, instead of mathematically:
   Code Example: \(x = {-b \pm \sqrt{b^2-4ac} \over 2a}\)
   I.e. voice reader is corrupt.

3. Highlighting a fragment of page which contains an expression, does not highlight these expression, making a "spagetty highlight".

4. Native MathJax tabbing still works, but initially without sound.
   Fortunately, this tabbling does not interfere with generic reader.

5. This is a MathJax v2.7.9 using local TeX fonts
   A bit old.
 
The test conducted on Chrome
Version 152.0.7977.64 (Official Build) (x86_64)
usually, by enabling "Menu/Settings/MoreTools/Reading Mode"